Prelimbic Prefrontal Neurons Drive Fear Expression: A Clue for Extinction-Reconsolidation Interactions
نویسندگان
چکیده
منابع مشابه
Prelimbic prefrontal neurons drive fear expression: a clue for extinction--reconsolidation interactions.
Learning associations between cues in the environment gives organisms the ability to predict impending danger. The last few decades of research have established that these stimulus– danger or fear associations are formed in the amygdala (LeDoux, 2000). This type of learning is modeled in the laboratory by presenting a neutral sensory stimulus (such as a tone) with an aversive stimulus (such as ...
متن کاملSustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure.
During auditory fear conditioning, it is well established that lateral amygdala (LA) neurons potentiate their response to the tone conditioned stimulus, and that this potentiation is required for conditioned fear behavior. Conditioned tone responses in LA, however, last only a few hundred milliseconds and cannot be responsible for sustained fear responses to a tone lasting tens of seconds. Rece...
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Retrieval labilizes memory traces and these gates two protein synthesis-dependent processes in the brain: extinction, which inhibits further retrieval, and reconsolidation, which may enhance retrieval or change its content. Extinction may itself suffer reconsolidation. Interactions among these processes may be applied to treatments of fear memories, such as those underlying post-traumatic stres...
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The prelimbic cortex has been implicated in the consolidation of previously learned fear. Herein, we report that temporarily inactivating this medial prefrontal cortex subregion with the GABAA agonist muscimol (4.0 nmol in 0.2 μL per hemisphere) was able to equally disrupt 1-, 7-, and 21-d-old contextual fear memories after their brief retrieval in rats. In all cases, this effect was prevented ...
متن کاملRetrieval and Reconsolidation Accounts of Fear Extinction
Extinction is the primary mode for the treatment of anxiety disorders. However, extinction memories are prone to relapse. For example, fear is likely to return when a prolonged time period intervenes between extinction and a subsequent encounter with the fear-provoking stimulus (spontaneous recovery). Therefore there is considerable interest in the development of procedures that strengthen exti...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2009
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4299-09.2009